Rapid assessment of the osteogenic capacity of hydroxyapatite/aragonite using a murine tibial periosteal ossification model

Biomaterials are widely used as orthopaedic implants and bone graft substitutes. We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2–4 weeks. A novel hydroxyapatite...

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Veröffentlicht in:	Bioactive materials 2025-03, Vol.45, p.257-273
Hauptverfasser:	Steijvers, Emma, Shi, Yunsong, Lu, Hong, Zhang, Weixin, Zhang, Yitian, Zhao, Feihu, Wang, Baichuan, Hughes, Louise, Barralet, Jake E., Degli-Alessandrini, Giulia, Kraev, Igor, Johnston, Richard, Shao, Zengwu, Ebetino, Frank H., Triffitt, James T., Russell, R. Graham G., Deganello, Davide, Cao, Xu, Xia, Zhidao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aragonite Assessments Biocompatibility Biodegradation Biomaterials Biomedical materials Bisphosphonates Bone biomaterials Bone grafts Bone growth Bone implants Bone remodeling Bones Calcium carbonate Callus Cancellous bone Cortical bone Defects Diameters Electron back scatter Femur Fractures Grafting Hydroxyapatite Hydroxyapatite/aragonite Intramembraneous bone Intramembranous ossification Orthopaedic implants Orthopedics Ossification Osteogenesis Osteogenesis assessment Regulatory approval Scanning electron microscopy Sheep Skeletal muscle Skin & tissue grafts Stem cells Substitute bone Surgical implants Thickness Tibia Tibial periosteal bone formation Tibialis anterior muscle X-ray spectroscopy Zoledronic acid
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Zusammenfassung:	Biomaterials are widely used as orthopaedic implants and bone graft substitutes. We aimed to develop a rapid osteogenic assessment method using a murine tibial periosteal ossification model to evaluate the bone formation/remodelling potential of a biomaterial within 2–4 weeks. A novel hydroxyapatite/aragonite (HAA) biomaterial was implanted into C57BL/6 mice juxtaskeletally between the tibia and tibialis anterior muscle. Rapid intramembranous bone formation was observed at 14 days, with 4- to 8-fold increases in bone thickness and callus volume in comparison with sham-operated animals (p
ISSN:	2452-199X 2097-1192 2452-199X
DOI:	10.1016/j.bioactmat.2024.11.025