Oral administration of recombinant Bacillus subtilis spores expressing mutant staphylococcal enterotoxin B provides potent protection against lethal enterotoxin challenge

Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and SEB were expressed in pET28a prokaryotic plasmids. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in mSEB-s...

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Veröffentlicht in:	AMB Express 2020-12, Vol.10 (1), p.215-9, Article 215
Hauptverfasser:	Xiong, Zhile, Mai, Jialiang, Li, Fei, Liang, Bingshao, Yao, Shuwen, Liang, Zhuwei, Zhang, Chao, Gao, Fei, Ai, Xiaolan, Wang, Jielin, Long, Yan, Yang, Min, Gong, Sitang, Zhou, Zhenwen
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Bacillus subtilis Biomedical and Life Sciences Biotechnology Exotoxins Fusion protein Gene expression Genetic aspects Identification and classification Immune response (humoral) Immune system Immunogenicity Immunoglobulin A Immunoglobulin G Interleukin 6 Life Sciences Lipopolysaccharides Macrophages Microbial Genetics and Genomics Microbiology Mutants Oral administration Original Original Article Pathogenicity Plasmids Properties Spores Spores (Botany) Staphylococcal enterotoxin A Staphylococcal enterotoxin B Staphylococcus aureus Tumor necrosis factor-TNF Tumor necrosis factor-α Vaccination
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Zusammenfassung:	Pathogenicity of Staphylococcus aureus is induced by staphylococcal enterotoxin B (SEB). A mutant form of SEB (mSEB) is immunogenic as well as less toxic. Recombinant mSEB and SEB were expressed in pET28a prokaryotic plasmids. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in mSEB-stimulated macrophages were lower than those in SEB-stimulated macrophages ( p
ISSN:	2191-0855 2191-0855
DOI:	10.1186/s13568-020-01152-x