Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis

Background Clinical diabetic traits have been reported to be associated with increased colorectal cancer (CRC) risk in observational studies. Using the Mendelian randomization (MR) analysis method, we examined the causal association between glycemic traits, such as fasting glucose (FG), fasting insu...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2024-03, Vol.13 (5), p.e7084-n/a
Hauptverfasser:	Jun, So Yon, Cho, Sooyoung, Kim, Min Jung, Park, Ji Won, Ryoo, Seung‐Bum, Jeong, Seung Yong, Park, Kyu Joo, Shin, Aesun
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Glucose Colon cancer Colonic Neoplasms Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Datasets Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Epidemiology Estimates Fasting Genome-Wide Association Study Glucose Glycated Hemoglobin glycemic traits Hemoglobin Humans Hyperglycemia Insulin Insulin resistance Laboratory testing Medical prognosis Mendelian Randomization Analysis Mortality Patients Polymorphism, Single Nucleotide Population Quality control Republic of Korea Sensitivity analysis Single-nucleotide polymorphism Survival Survival analysis Type 2 diabetes
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Zusammenfassung:	Background Clinical diabetic traits have been reported to be associated with increased colorectal cancer (CRC) risk in observational studies. Using the Mendelian randomization (MR) analysis method, we examined the causal association between glycemic traits, such as fasting glucose (FG), fasting insulin (FI), and glycosylated hemoglobin A1c (HbA1c), and survival in a cohort of CRC patients. Methods We conducted a two‐sample MR analysis among a cohort of patients with locally advanced CRC at Seoul National University Hospital. Single‐nucleotide polymorphisms robustly associated (p
ISSN:	2045-7634 2045-7634
DOI:	10.1002/cam4.7084