Regulatory T cells participate in the recovery of ischemic stroke patients

Regulatory T cells participate in the recovery of ischemic stroke patients

Background Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and outcome in h...

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Veröffentlicht in:BMC neurology 2020-02, Vol.20 (1), p.68-68, Article 68
Hauptverfasser: Santamaria-Cadavid, Maria, Rodriguez-Castro, Emilio, Rodriguez-Yanez, Manuel, Arias-Rivas, Susana, Lopez-Dequidt, Iria, Perez-Mato, Maria, Rodriguez-Perez, Manuel, Lopez-Loureiro, Ignacio, Hervella, Pablo, Campos, Francisco, Castillo, Jose, Iglesias-Rey, Ramon, Sobrino, Tomas
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Care and treatment
Cerebrovascular diseases
Clinical Neurology
Clinical trials
Disease
Early neurological deterioration
Flow cytometry
Health aspects
Immune response
Immunoregulation
Industrialized nations
Infection
Infections
Inflammation
Interleukin-10
Interleukins
Ischemia
Ischemic stroke
Laboratories
Life Sciences & Biomedicine
Lymphocytes T
Medical imaging
Neuroinflammation
Neurosciences & Neurology
Patient outcomes
Patients
Physiological aspects
Regulatory T cells
Risk factors
Science & Technology
Software
Stroke
Studies
Suppressor cells
T cells
Variables
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Zusammenfassung:Background Recent preclinical studies have shown that regulatory T cells (Treg) play a key role in the immune response after ischemic stroke (IS). However, the role of Treg in human acute IS has been poorly investigated. Our aim was to study the relationship between circulating Treg and outcome in human IS patients. Methods A total of 204 IS patients and 22 control subjects were recruited. The main study variable was good functional outcome at 3 months (modified Rankin scale
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-020-01648-w