An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide

An Improved Process for the Preparation of an ?,?-Difluorosulfonylisoxazoline Herbicide

An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chimia 2014-06, Vol.68 (6), p.442
Hauptverfasser: Belie, Chantal, Plant, Andrew, Mulholland, Nick, McLachlan, Matthew, McCormack, Derek, Longstaff, Adrian, Kozakiewicz, Tony, Knee, Andy, Ingram, Katharine, Qacemi, Myriem El, Diggelmann, Martin, Dallimore, Jonathan, Dalençon, Anne, Clarke, Eric, Boehmer, Jutta, Williams, John
Format: Artikel
Sprache:eng
Schlagworte:
Defluorinative silylation
Herbicide
Process chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:An efficient synthesis of a difluorosulfone-containing herbicide has been achieved by selective reductive silylation of a symmetrical bis(trifluoromethyl)-1,2,3-triazole. Subsequently, a fluoride-induced reaction led to a difluoromethyl anion equivalent, which was reacted with a sulfur electrophile leading ultimately to the key difluorosulfide moiety.
ISSN:0009-4293
2673-2424
DOI:10.2533/chimia.2014.442