Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators

Synthesis and Photolytic Assessment of Nitroindolinyl-Caged Calcium Ion Chelators

Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, ni...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2022-04, Vol.27 (9), p.2645
Hauptverfasser: Papageorgiou, George, Corrie, John E T
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acids
By products
Calcium
Calcium - metabolism
Calcium Chelating Agents
calcium chelators
Calcium ions
Chelating Agents
chemical synthesis
Ethylenediaminetetraacetic acids
Ions
Laboratories
nitroindoline cages
Photolysis
photostability
Reagents
Spectrum analysis
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Beschreibung
Zusammenfassung:Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-µs release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27092645