Assessment of Seroprevalence to SARS-CoV-2 in Various Population Cohorts Using Logit Regression Models During Initial Period of Herd Immunity Formation

The aim of the study was to assess the dynamics of seroprevalence to SARS-CoV-2 in various population groups during the initial period of herd immunity formation based on multivariate analysis using logit regression models. Materials and methods . The study involved 1561 individuals divided into three population cohorts: people living with HIV/AIDS (PLHA), healthy blood donors, medical workers. The presence of antibodies to SARS-CoV-2 was determined in blood serum through ELISA using commercial reagent kits. Multivariate analysis of the dynamics of seroprevalence to SARS-CoV-2 was carried out using logistic regression models. Results and discussion . It has been revealed that probability of detecting IgG antibodies to SARS-CoV-2 significantly increased among the donors and medical workers in the spring-autumn 2020 series (p=0.005 и p