In Regard to Otelea et al

To the Editor, Otelea et al. (1) reported in one of your recent issues their study findings on the cross-sectional correlation between the leptin-to-adiponectin ratio and unfavorable plasma lipid profile in 93 predominantly nonobese, healthy young adult women. The researchers reported a significant relationship between high leptin–adiponectin ratio and cardiometabolic risk indicators such as anthropometric measurements, plasma atherogenic index, lipid accumulation product, and insulin resistance in the healthy young adult population, while no relationship has been reported between low-grade inflammatory markers such as interleukin-6 and high-sensitivity C-reactive protein. These findings suggest that high leptin–adiponectin ratio may be a good indicator in the evaluation of cardiovascular and metabolic risk in the nonobese healthy young population (1).