SOME CLINICAL-THERAPEUTIC FEATURES OF ALCOHOL ENCEPHALOPATHIES

The article points out that alcoholism for modern society is a significant medico-social problem due to the progressive increase in the prevalence of this disease throughout the world; tendencies to its significant rejuvenation and the large economic, medical, social and other social losses inflicted on society by this disease. The article reveals the main manifestations of the clinical picture of alcohol dependence, which is psycho-neurological symptoms. Also the clinical and therapeutic features of one of the most significant problems of modern psychoneurology - alcoholism and alcohol encephalopathy are outlined. On the basis of literature data, the general principles of the occurrence of this pathology are shown, its main clinical forms with the characteristic of leading symptomatic manifestations are described, the main therapeutic principles of intervention in this problem are revealed. It was stated that during the treatment of acute alcoholic encephalopathy, the etiological factors and concomitant somatic pathology must be taken into account. It was found that the basic eiological mechanisms of action are: - enhancement of microcirculation and improvement of brain metabolism (Cavinton, Trental, Tanacan, Stugeron, Nootropil, Encephabol, etc. are used); - inhibition of platelet aggregation and erythrocytes (using antiplatelet agents - chimes, acetylsalicylic acid, etc.); - conducting hypolipidemic (clofibrate, fenofibrate, nicotinic acid, etc.) and antihypertensive therapy (use of ACE inhibitors (renitec, enap, etc.), Ca antagonists (finoptin, etc.) and beta-blockers (atenolol, etc.)); - correction of psycho-emotional manifestations (use of tranquilizers, antidepressants and anxiolytics); - reduction of mental disorders (use of peptide biostimulants - Cortexin, timogen, epithalamin. The work carried out has led to the conclusion that clinical and etiological manifestations, therapeutic mechanisms, types of course and other features of alcoholic encephalopathies, as well as issues of various disorders of the central nervous system, especially higher mental functions in the abuse of alcohol and alcohol-containing substances are extremely important and relevant to modern psychoneurology and addiction problems.