Effects of rocuronium, sugammadex and rocuronium-sugammadex complex on coagulation in rats

Sugammadex is an alternative pharmacological drug capable of reversing neuromuscular blockades without the limitations that are presented by anticholinesterase drugs. Coagulation disorders that are related to treatment with sugammadex were reported. The exact mechanism of the effects on coagulation are not fully understood. The objective of this research is to evaluate the effects of rocuronium, sugammadex and the rocuronium-sugammadex complex on coagulation in an experimental model in rats. This is an experimental randomized animal study. Wistar rats were randomly assigned into the following groups: the Control Group; the Ssal Group – 0.5mL of intravenous saline; the Sugammadex Group – intravenous sugammadex (100mgkg−1); and the Rocuronium-Sugammadex Group – intravenous solution with rocuronium (3.75mgkg−1) and sugammadex (100mgkg−1). Anesthesia was performed by using isoflurane with controlled ventilation. Coagulation factors were measured 10minutes after the end of the preoperative preparation and 30minutes after the administration of the drugs in accordance with the chosen groups. Platelet counts, prothrombin times, and activated partial thromboplastin times were similar between the groups and between the moments within each group. There were reductions in the plasma fibrinogen levels between sample times 1 and 2 in the Rocuronium-Sugammadex group (p=0.035). The rocuronium-sugammadex complex promoted reductions in plasma fibrinogen counts, although the levels were still within normal limits. O sugamadex é uma substância farmacológica alternativa capaz de reverter o bloqueio neuromuscular sem as limitações apresentadas pelos anticolinesterásicos. Entretanto, há relatos de transtornos de coagulação relacionados ao tratamento com sugamadex sem que mecanismos exatos de seus efeitos sobre a coagulação sejam totalmente compreendidos. O objetivo da presente pesquisa foi avaliar os efeitos de rocurônio, sugamadex e do complexo rocurônio-sugamadex sobre a coagulação em um modelo experimental com ratos. Este é um estudo randomizado experimental animal. Ratos Wistar foram aleatoriamente designados aos seguintes grupos: grupo controle; Grupo Ssal – 0,5mL de solução salina intravenosa; Grupo sugamadex – sugamadex intravenoso (100mgkg−1); e Grupo rocurônio-sugamadex – solução intravenosa com rocurônio (3,75mgkg−1) e sugamadex (100mgkg−1). A anestesia foi realizada utilizando-se isoflurano com ventilação controlada. Os fatores de coagulação foram medidos 10minutos ap