Evaluation on variability and safety of serum trough concentrations of vancomycin in patients admitted to intensive care unit

Highlights • Vancomycin trough concentration in ICU patients varies significantly. • Gender, age and eGFR are independent factors affecting the trough concentration. • The fixed dose regimen of 2 g/d in ICU patients may be inappropriate. • Dose should be individualized based on weight, age and renal...

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Veröffentlicht in:	International journal of infectious diseases 2017-07, Vol.60 (C), p.17-22
Hauptverfasser:	Qian, Xiaodan, Du, Guantao, Weng, Chunmei, Zhou, Haijun, Zhou, Xianju
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Aged Aged, 80 and over Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Body Weight China Critical Care Drug Monitoring Female Glomerular Filtration Rate Hospitalization Hospitals Humans Incidence Infectious Disease Intensive Care Units Kidney - drug effects Male Middle Aged Pulmonary/Respiratory Renal function Retrospective Studies Safety Serum trough concentration Sex Vancomycin Vancomycin - blood Vancomycin - pharmacokinetics Vancomycin - therapeutic use
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Zusammenfassung:	Highlights • Vancomycin trough concentration in ICU patients varies significantly. • Gender, age and eGFR are independent factors affecting the trough concentration. • The fixed dose regimen of 2 g/d in ICU patients may be inappropriate. • Dose should be individualized based on weight, age and renal function.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2017.04.018