Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management

We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomanna...

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Veröffentlicht in:	Revista da Sociedade Brasileira de Medicina Tropical 2020-01, Vol.53, p.e20200401-e20200401
Hauptverfasser:	Santana, Monique Freire, Pivoto, Guilherme, Alexandre, Márcia A Araujo, Baía-da-Silva, Djane Clarys, Borba, Mayla Gabriela da Silva, Val, Fernando Almeida, Brito-Sousa, Jose Diego, Melo, Gisely Cardoso, Monteiro, Wuelton Marcelo, Souza, João Vicente Braga, Pinheiro, Silviane Bezerra, Ferreira, Luiz Carlos Lima, Naveca, Felipe Gomes, Nascimento, Valdinete Alves, Corado, André Lima Guerra, Hajjar, Ludhmila Abrahão, Silva Neto, João Ricardo, Siva, George Alan Villarouco, Pasqualotto, Alessandro C, Lacerda, Marcus Vinícius Guimarães
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aspergillus Aspergillus - genetics Aspergillus - isolation & purification Autopsy Betacoronavirus Case Report Coronavirus Infections - complications Coronavirus Infections - pathology COVID-19 Fatal Outcome Humans Invasive Pulmonary Aspergillosis - complications Invasive Pulmonary Aspergillosis - pathology Lung - microbiology Male Pandemics Pneumonia, Viral - complications Pneumonia, Viral - pathology Postmortem evidence SARS-CoV-2 TROPICAL MEDICINE
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Zusammenfassung:	We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.
ISSN:	0037-8682 1678-9849 1678-9849
DOI:	10.1590/0037-8682-0401-2020