The role of uromodulin in cardiovascular disease: a review

Uromodulin, also referred to as Tamm Horsfall protein (THP), is a renal protein exclusively synthesized by the kidneys and represents the predominant urinary protein under normal physiological conditions. It assumes a pivotal role within the renal system, contributing not only to ion transport and i...

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Veröffentlicht in:Frontiers in cardiovascular medicine 2024-07, Vol.11, p.1417593
Hauptverfasser: Chen, Chengqian, Zhong, Wentao, Zheng, Hao, Dai, Gaoying, Zhao, Wei, Wang, Yushi, Dong, Qi, Shen, Botao
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Sprache:eng
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Zusammenfassung:Uromodulin, also referred to as Tamm Horsfall protein (THP), is a renal protein exclusively synthesized by the kidneys and represents the predominant urinary protein under normal physiological conditions. It assumes a pivotal role within the renal system, contributing not only to ion transport and immune modulation but also serving as a critical factor in the prevention of urinary tract infections and kidney stone formation. Emerging evidence indicates that uromodulin may serve as a potential biomarker extending beyond renal function. Recent clinical investigations and Mendelian randomization studies have unveiled a discernible association between urinary regulatory protein levels and cardiovascular events and mortality. This review primarily delineates the intricate relationship between uromodulin and cardiovascular disease, elucidates its predictive utility as a novel biomarker for cardiovascular events, and delves into its involvement in various physiological and pathophysiological facets of the cardiovascular system, incorporating recent advancements in corresponding genetics.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2024.1417593