Investigation of the Anticancer Activity of Coordination-Driven Self-AssembledTwo-Dimensional Ruthenium Metalla-Rectangle

Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [( - -cymene) Ru (C H O ) ( ) ](CF SO ) ( ) by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru ( - -cymene) (C H O )Cl ] ( ) and bis-pyridyl amide linker ( ) in the presence of AgO SCF . This cationic ruthenium metalla-rectangle ( ) has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy ( H-NMR), carbon nuclear magnetic resonance spectroscopy ( C-NMR), H- H correlation spectroscopy (COSY), H- H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex ( ) and the commercially used drug, cisplatin.