The Roles of CD147 and/or Cyclophilin A in Kidney Diseases

CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both...

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Veröffentlicht in:	Mediators of Inflammation 2014-01, Vol.2014 (7), p.234-243
Hauptverfasser:	Qie, Guoqiang, Zhang, Jicheng, Wang, Chunting, Qu, Xin, Zhou, Jianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - pathology Animals Asthma Basigin - metabolism Carcinoma, Renal Cell - metabolism Cardiovascular disease Caveolin 1 - metabolism Cyclophilin Cyclophilin A - metabolism Extracellular matrix Fibrosis - physiopathology Gene Expression Regulation Health aspects Hospitals Humans Inflammation Integrins - metabolism Kidney diseases Kidney Diseases - metabolism Kidney Neoplasms - metabolism Kinases Liver Mice Nephritis - metabolism Physiological aspects Polymerization Protein folding Review RNA, Small Interfering - metabolism Rodents Roles Signal Transduction Studies T cells
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Beschreibung
Zusammenfassung:	CD147 is a widely expressed integral plasma membrane glycoprotein and has been involved in a variety of physiological and pathological activities in combination with different partners, including cyclophilins, caveolin-1, monocarboxylate transporters, and integrins. Recent data demonstrate that both CyPA and CD147 significantly contribute to renal inflammation, acute kidney injury, renal fibrosis, and renal cell carcinoma. Here we review the current understanding of cyclophilin A and CD147 expression and functions in kidney diseases and potential implications for treatment of kidney diseases.
ISSN:	0962-9351 1466-1861
DOI:	10.1155/2014/728673