Advances in the study of the role of estrogen and its receptor combined with HPV in cervical cancer microenvironment

Human papillomavirus (HPV) infection is related to cervical cancer. Estrogen and its receptor combined with HPV oncogene can promote the occurrence of cervical cancer. Moreover, high parity and the use of contraceptives incrcasing the risk of cervical cancer support estrogen and HPV infection synergistically promotes cervical cancer. Estrogen can both combine with HPV responsive elements to change viral gene expression accelerating the process of HPV infection, and develop HPV-positive cervical cancer by exerting immunomodulatory function in tumor microenvironment. Estrogen and its receptor play vital roles in cervical cancer and are expected to be a potential therapeutic target for treatment of cervical cancer.