Studies towards the synthesis of hyperireflexolide A

Studies towards the synthesis of hyperireflexolide A

The first approach to hyperireflexolide A, based on the synthesis of γ-lactone-fused cyclopentane , a functionalized key intermediate, is presented. Compound is involved in hydrolysis, α-allylation at C-8 and α-methylation at C-10 stereoselectively from the convex face. Then it is subjected to cross...

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Veröffentlicht in:Beilstein journal of organic chemistry 2018-08, Vol.14 (1), p.2106-2111
1. Verfasser: Rao, G Hari Mangeswara
Format: Artikel
Sprache:eng
Schlagworte:
alkylation
allylation
Chemistry
Chromatography
cross metathesis
Cyclopentane
Full Research Paper
hyperireflexolide A
Methylation
spiroterpene
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Beschreibung
Zusammenfassung:The first approach to hyperireflexolide A, based on the synthesis of γ-lactone-fused cyclopentane , a functionalized key intermediate, is presented. Compound is involved in hydrolysis, α-allylation at C-8 and α-methylation at C-10 stereoselectively from the convex face. Then it is subjected to cross metathesis to give α β-unsaturated ketone as precursor in the total synthesis of hyperireflexolide A.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.14.185