Clinical relevance of circulating MACC1 and S100A4 transcripts for ovarian cancer

Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy an...

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Veröffentlicht in:	Molecular oncology 2019-05, Vol.13 (5), p.1268-1279
Hauptverfasser:	Link, Theresa, Kuhlmann, Jan Dominik, Kobelt, Dennis, Herrmann, Pia, Vassileva, Yana D., Kramer, Michael, Frank, Kerstin, Göckenjan, Maren, Wimberger, Pauline, Stein, Ulrike
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers Biopsy blood‐based biomarker Breast cancer Calcium-binding protein Cancer Cancer therapies Cell-Free Nucleic Acids - blood Chemotherapy Colon cancer Colorectal cancer Comparative analysis Development and progression Disease-Free Survival Female Gastric cancer Humans Kinases MACC1 Medical prognosis Metastases Metastasis Middle Aged Ovarian cancer Ovarian Neoplasms - blood Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Patients Polymerase chain reaction prognosis Protein binding Proteins Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - blood RNA, Neoplasm - blood S100 Calcium-Binding Protein A4 S100A4 S100A4 protein Serum levels Surgery Survival Survival Rate Trans-Activators Tumors
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Zusammenfassung:	Metastasis‐associated in colon cancer 1 (MACC1) and S100 calcium‐binding protein A4 (S100A4) are prominent inducers of tumor progression and metastasis. For the first time, we systematically tracked circulating serum levels of MACC1 and S100A4 transcripts in the course of surgery and chemotherapy and analyzed their clinical relevance for ovarian cancer. MACC1 and S100A4 transcripts were quantified in a total of 318 serum samples from 79 ovarian cancer patients by RT‐qPCR and digital droplet PCR, respectively. MACC1 and S100A4 transcripts were significantly elevated in serum of ovarian cancer patients, compared to healthy controls (P = 0.024; P
ISSN:	1574-7891 1878-0261
DOI:	10.1002/1878-0261.12484