Identification of Novel Human Breast Carcinoma (MDA-MB-231) Cell Growth Modulators from a Carbohydrate-Based Diversity Oriented Synthesis Library

The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2 -furo[3,2- ][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological s...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2016-10, Vol.21 (10), p.1405-1405
Hauptverfasser:	Lenci, Elena, Innocenti, Riccardo, Biagioni, Alessio, Menchi, Gloria, Bianchini, Francesca, Trabocchi, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomimetics Blood pressure Breast cancer Breast Neoplasms - drug therapy cancer Carbohydrates Carbohydrates - chemistry Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Cell Survival - drug effects chemical diversity Diabetes Drug Screening Assays, Antitumor - methods Female Growth Inhibitors - chemical synthesis Growth Inhibitors - chemistry Growth Inhibitors - pharmacology heterocycles Humans Metabolic disorders Molecular Structure Natural products Nitrogen Oxazines - chemical synthesis Oxazines - chemistry Oxazines - pharmacology Pharmaceutical industry Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology sugars Toxicity
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Zusammenfassung:	The application of a cell-based growth inhibition on a library of skeletally different glycomimetics allowed for the selection of a hexahydro-2 -furo[3,2- ][1,4]oxazine compound as candidate inhibitors of MDA-MB-231 cell growth. Subsequent synthesis of analogue compounds and preliminary biological studies validated the selection of a valuable hit compound with a novel polyhydroxylated structure for the modulation of the breast carcinoma cell cycle mechanism.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules21101405