Resveratrol modulates ferroptosis: Promising therapeutic targets in ischemia-reperfusion

Ischemia-reperfusion (I/R) injury is an inevitable pathological process in many clinical practices, such as transplantation, myocardial infarction, cerebral infarction and current treatments for I/R injury are limited. Ferroptosis is an essential pathogenic mechanism for triggering I/R injury, characterized by excess reactive oxygen species (ROS) accompanied by lipid peroxidation and increased intracellular iron concentration consistent with the mechanical manifestations of I/R. Resveratrol (RES) is a polyphenolic compound found in red wine that acts as an iron chelator, lipophilic antioxidant, and lipid peroxidation inhibitor. It helps to inhibit I/R damage by reversing ferroptosis-induced cell death, providing insights into developing therapeutic strategies for this devastating disease. In this review, we used the keywords “ferroptosis”, “resveratrol”, and “ischemia-reperfusion” in conjunction with each other, collected 1039 papers from the last decade, 114 relevant papers were screened to review the research progress on the mitigating of I/R injury through ferroptosis in Res and its future perspectives.