Clean and efficient synthesis of isoxazole derivatives in aqueous media

Clean and efficient synthesis of isoxazole derivatives in aqueous media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environ...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2013-11, Vol.18 (11), p.13645-13653
Hauptverfasser: Dou, Guolan, Xu, Pan, Li, Qiang, Xi, Yukun, Huang, Zhibin, Shi, Daqing
Format: Artikel
Sprache:eng
Schlagworte:
5-arylisoxazole
aqueous media
Hydroxylamine - chemistry
Isoxazoles - chemistry
Molecular Structure
synthesis
Water
without catalyst
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Beschreibung
Zusammenfassung:A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules181113645