Fixed Drug Eruption Caused by Fluconazole: A Case Report and Mini-Review of the Literature

A fixed drug eruption (FDE) characteristically recurs at the same site or sites each time the drug administered.1 Acute lesions usually develop 30 minutes to 8 hours after drug administration as sharply marginated, round or oval itchy plaques of erythema and edema that become dusky violaceous or brown, and sometimes vesicular or bullous.1 Antibacterial drugs, non-steroidal anti-inflammatory drugs, barbiturates and other tranquillizers, phenolphthalein and related compounds are commonly implicated agents.1 However, oral antifungal agents are rarely associated with FDE. Here, we report the case of a 34-year-old woman diagnosed with FDE due to oral fluconazole and review the 16 similar cases (including this one) in the English language literature.2-16 A34-year-old Canadian woman was referred to our department for diagnosis of a slight pigmented macule on the right elbow and faint erythema with scale on the left elbow (Fig. 1a, b). She reported that she had woken up with two red erythematous macules with a burning sensation on the elbows 9 days earlier.