Efficacy of human epididymis protein-IV as potential lung disease biomarker in comparison to Krebs von den Lungen-VI glycoprotein and apoprotein A2 among systemic sclerosis patients

Background Systemic sclerosis is a connective tissue disease of unknown etiology, characterized by vasculopathy, fibrosis, inflammation, and immune dysregulation that lead to widespread internal organs fibrosis, chronic ischemia, and subsequent end-stage organ failure. Our purpose was to examine the role of human epididymis protein IV as a biomarker of interstitial lung disease severity in comparison to Krebs von den Lungen-VI glycoprotein and apoprotein A2 among systemic sclerosis patients. Results There was a highly significant elevation of serum human epididymis protein IV between systemic sclerosis patients (both with and without interstitial lung disease) and the control group ( p