Vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy: a case report and literature review

Pseudo-thrombotic microangiopathy (pseudo-TMA) is a recognized, yet uncommon, clinical presentation of vitamin B12 deficiency. Patients with pseudo-TMA present with microangiopathic hemolytic anemia (MAHA), thrombocytopenia and schistocytes. They are often misdiagnosed as thrombotic thrombocytopenia...

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Veröffentlicht in:	Clinical pharmacology: advances and applications 2019-08, Vol.11, p.127-131
Hauptverfasser:	Fahmawi, Yazan, Campos, Yesica, Khushman, Moh'd, Alkharabsheh, Omar, Manne, Ashish, Zubair, Haseeb, Haleema, Saadia, Polski, Jacek, Bessette, Sabrina
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Antibodies Autoantibodies Autoimmunity Blood Blood platelets Case Report Case reports Diagnosis Emergency medical care Glycosylated hemoglobin Hemoglobin Hemoglobins Hemolysis Hemolytic anemia Internal medicine Neutrophils Patients Pernicious anemia Plasma exchange (Therapeutics) Pseudo-thrombotic microangiopathy Purpura Schistocytes Stem cells Thrombocytopenia Transplants & implants Vitamin B12 deficiency Vitamin deficiency Vitamins
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Zusammenfassung:	Pseudo-thrombotic microangiopathy (pseudo-TMA) is a recognized, yet uncommon, clinical presentation of vitamin B12 deficiency. Patients with pseudo-TMA present with microangiopathic hemolytic anemia (MAHA), thrombocytopenia and schistocytes. They are often misdiagnosed as thrombotic thrombocytopenia purpura (TTP) and receive unnecessary therapy. Here, we report a case of a 60-year-old male who presented with thrombocytopenia and normocytic normochromic anemia. Anemia work-up was remarkable for severe B12 deficiency (
ISSN:	1179-1438 1179-1438
DOI:	10.2147/CPAA.S207258