Correlation between rs3740051 polymorphism of SIRT1 gene and volume of brain gray matter in depression patients

Objective To investigate the correlation between the polymorphism of SIRT1 locus rs3740051 and the structure of brain gray matter in patients with first-onset untreated depression as well as in healthy controls. Methods Clinical data of 75 patients (15 males and 60 females) with first-onset depression treated in our hospital from March 2018 to September 2019 were recruited, and another 43 volunteers were enrolled as healthy controls. Their brain structural data were collected from high resolution images after magnetic resonance imaging, and the allelic and genotypic frequencies of rs3740051 polymorphisms of SIRT1 gene were determined with DNA sequencing in the 2 groups. Based on the detected genotypes, the depression patients and healthy controls were classified into 4 groups: depression (AA), depression (AG/GG), control (AA) and control (AG/GG) groups. The interaction effects of SIRT1 rs3740051 genotypes (AA or AG/GG) and disease diagnosis (depression or control), as well as their respective main effects on