Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile Infections among Adults, Canada, 2015-2019

We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015-2019. The study encompassed 18,455 CDI cas...

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Veröffentlicht in:	Emerging infectious diseases 2022-06, Vol.28 (6), p.1128-1136
Hauptverfasser:	Du, Tim, Choi, Kelly B, Silva, Anada, Golding, George R, Pelude, Linda, Hizon, Romeo, Al-Rawahi, Ghada N, Brooks, James, Chow, Blanda, Collet, Jun C, Comeau, Jeannette L, Davis, Ian, Evans, Gerald A, Frenette, Charles, Han, Guanghong, Johnstone, Jennie, Kibsey, Pamela, Katz, Kevin C, Langley, Joanne M, Lee, Bonita E, Longtin, Yves, Mertz, Dominik, Minion, Jessica, Science, Michelle, Srigley, Jocelyn A, Stagg, Paula, Suh, Kathryn N, Thampi, Nisha, Wong, Alice, Hota, Susy S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibiotics Antimicrobial agents antimicrobial resistance bacteria C. difficle Canada - epidemiology Characterization of Healthcare-Associated and Community-Associated Clostridioides difficile - genetics Clostridioides difficile infection Clostridium infections Clostridium Infections - drug therapy Clostridium Infections - epidemiology Community-acquired infections community-associated infections Cross infection Cross Infection - epidemiology Delivery of Health Care Drug resistance Epidemiology Health care healthcare-associated infections Humans Infections among Adults, Canada, 2015–2019 Laboratories Microbial Sensitivity Tests Mortality Nosocomial infection Nosocomial infections Patient outcomes Patients Ribotyping Risk factors Statistics Surveillance Trends
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Zusammenfassung:	We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015-2019. The study encompassed 18,455 CDI cases, 13,735 (74.4%) HA and 4,720 (25.6%) CA. During 2015-2019, HA CDI rates decreased by 23.8%, whereas CA decreased by 18.8%. HA CDI was significantly associated with increased 30-day all-cause mortality as compared with CA CDI (p
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2806.212262