Body mass index and clinical outcomes in patients with heart failure with preserved ejection fraction mediated by diastolic blood pressure status?

Body mass index and clinical outcomes in patients with heart failure with preserved ejection fraction mediated by diastolic blood pressure status?

The “obesity paradox” has been elucidated in patients with heart failure (HF). Current guidelines introduce a target diastolic blood pressure (DBP) 70 mmHg in HF patients. Due to reduced coronary perfusion, low DBP has a deleterious impact on cardiovascular outcomes. This present study aimed to asse...

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Veröffentlicht in:Heliyon 2023-06, Vol.9 (6), p.e16515-e16515, Article e16515
Hauptverfasser: Hu, YingQiu, Gu, ZhenBang, Xu, MeiLing, He, WenFeng, Wu, LiDong, Xu, ZhiCheng, Guo, LinJuan
Format: Artikel
Sprache:eng
Schlagworte:
Body mass index
Diastolic blood pressure
Heart failure
Obesity
Obesity paradox
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Zusammenfassung:The “obesity paradox” has been elucidated in patients with heart failure (HF). Current guidelines introduce a target diastolic blood pressure (DBP) 70 mmHg in HF patients. Due to reduced coronary perfusion, low DBP has a deleterious impact on cardiovascular outcomes. This present study aimed to assess the relationship between BMI and adjudicated clinical outcomes in HFpEF patients according to the status of DBP. We analyzed the data in 1749 HFpEF patients from the Americas of the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) Trial. The population was stratified by DBP (
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2023.e16515