Autoimmune polyglandular syndrome type 3: A case report of an unusual presentation and literature review

Autoimmune polyglandular syndromes (APS) are rare disorders characterized by auto‐destruction of endocrine and non‐endocrine organs by organ‐specific antibody‐directed T‐lymphocytic infiltration. This case highlights a 29‐year‐old Caucasian man with vitiligo found to have significant neurological abnormalities in the setting of newly diagnosed pernicious anemia and thyroid autoimmune disease. Autoimmune polyglandular syndromes can have widely variable presentations. If a patient is found to have newly diagnosed thyroid autoimmune disease, it would be valuable to screen for other autoimmune diseases such as pernicious anemia; as these associated endocrinopathies can lead to significant neurological consequences.