Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients

Monocyte Distribution Width (MDW) as novel inflammatory marker with prognostic significance in COVID-19 patients

Monocyte Distribution Width (MDW), a new cytometric parameter correlating with cytomorphologic changes occurring upon massive monocyte activation, has recently emerged as promising early biomarker of sepsis. Similar to sepsis, monocyte/macrophage subsets are considered key mediators of the life-thre...

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Veröffentlicht in:Scientific reports 2021-06, Vol.11 (1), p.12716-12716, Article 12716
Hauptverfasser: Riva, Giovanni, Castellano, Sara, Nasillo, Vincenzo, Ottomano, Anna Maria, Bergonzini, Giuliano, Paolini, Ambra, Lusenti, Beatrice, Milić, Jovana, De Biasi, Sara, Gibellini, Lara, Cossarizza, Andrea, Busani, Stefano, Girardis, Massimo, Guaraldi, Giovanni, Mussini, Cristina, Manfredini, Rossella, Luppi, Mario, Tagliafico, Enrico, Trenti, Tommaso
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Sprache:eng
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Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers
Biomarkers - blood
C-Reactive Protein - analysis
Cell activation
Cell Size
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - epidemiology
COVID-19 - virology
Cytokine storm
Cytokines
Female
Ferritin
Ferritins - blood
Fibrinogen
Fibrinogen - analysis
Humanities and Social Sciences
Humans
Immunopathogenesis
Inflammation - blood
Inflammatory diseases
Italy - epidemiology
Longitudinal Studies
Macrophages
Male
Middle Aged
Monocytes
Monocytes - pathology
multidisciplinary
Patient Admission
Patients
Pilot Projects
Prognosis
Retrospective Studies
SARS-CoV-2
Science
Science (multidisciplinary)
Sensitivity and Specificity
Sepsis
Severity of Illness Index
Young Adult
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Zusammenfassung:Monocyte Distribution Width (MDW), a new cytometric parameter correlating with cytomorphologic changes occurring upon massive monocyte activation, has recently emerged as promising early biomarker of sepsis. Similar to sepsis, monocyte/macrophage subsets are considered key mediators of the life-threatening hyper-inflammatory disorder characterizing severe COVID-19. In this study, we longitudinally analyzed MDW values in a cohort of 87 COVID-19 patients consecutively admitted to our hospital, showing significant correlations between MDW and common inflammatory markers, namely CRP ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-92236-6