Role of kif2c , A Gene Related to ALL Relapse, in Embryonic Hematopoiesis in Zebrafish

Relapse of acute lymphoblastic leukemia (ALL) is dangerous and it worsens the prognosis of patients; however, prognostic markers or therapeutic targets for ALL remain unknown. In the present study, using databases such as TARGET, GSE60926 and GSE28460, we determined that and its binding partner, are overexpressed in patients with relapsed ALL compared to that in patients diagnosed with ALL for the first time. As 50% of the residues are exactly the same and the signature domain of is highly conserved between human and zebrafish, we used zebrafish embryos as a model to investigate the function of in vivo. We determined that is necessary for lymphopoiesis in zebrafish embryos. Additionally, we observed that is not related to differentiation of HSCs; however, it is important for the maintenance of HSCs as it provides survival signals to HSCs. These results imply that the ALL relapse-related gene is linked to the survival of HSCs. In conclusion, we suggest that can serve as a novel therapeutic target for relapsed ALL.