The Role of Macrophages in Airway Disease Focusing on Porcine Reproductive and Respiratory Syndrome Virus and the Treatment with Antioxidant Nanoparticles

Lung macrophage cells play a critical role in various lung diseases, and their state can change depending on the progression of the disease by inducing either an inflammatory or anti-inflammatory state. In this review, the potential therapeutic effects of treatment with antioxidant nanoparticles in...

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Veröffentlicht in:	Viruses 2024-10, Vol.16 (10), p.1563
1. Verfasser:	Choi, Kyuhyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway management Allergic diseases alveolar macrophages Animal diseases Animals Antigens Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - immunology Antigens, Differentiation, Myelomonocytic - metabolism Antioxidants Antioxidants - pharmacology Asthma Bacterial infections Blood vessels Care and treatment CD163 antigen Chronic obstructive pulmonary disease Coronaviruses COVID-19 Cytokines Health aspects Hogs Homeostasis Humans Infections Lung cancer Lung diseases M1/M2 Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - virology Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - virology nanomaterials Nanoparticles Nanoparticles - chemistry Pathogenesis Physiological aspects Pneumonia Porcine reproductive and respiratory syndrome Porcine Reproductive and Respiratory Syndrome - drug therapy Porcine Reproductive and Respiratory Syndrome - immunology Porcine Reproductive and Respiratory Syndrome - virology Porcine respiratory and reproductive syndrome virus - immunology Porcine respiratory and reproductive syndrome virus - physiology Protein structure Proteins PRRSV Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Cell Surface - metabolism respiratory disease Respiratory diseases Respiratory tract diseases Review ROS Swine Tumor necrosis factor-TNF Viruses
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Zusammenfassung:	Lung macrophage cells play a critical role in various lung diseases, and their state can change depending on the progression of the disease by inducing either an inflammatory or anti-inflammatory state. In this review, the potential therapeutic effects of treatment with antioxidant nanoparticles in air-borne diseases focusing on porcine reproductive and respiratory virus (PRRSV), considering reactive oxygen species (ROS) as one of the factors that regulate M1 and M2 macrophages in the inflammatory and anti-inflammatory states, respectively, was described. In addition, the author examines the status of protein structure research on CD163 (one of the markers of anti-inflammatory M2 macrophages) in human and veterinary lung diseases.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v16101563