Rapid HIV disease progression following superinfection in an HLA-B27:05/B57:01-positive transmission recipient

The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B*27:05 and HLA-B*57:01. One subject maintained low-to-undetectable viral loa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Retrovirology 2018-01, Vol.15 (1), p.7-7, Article 7
Hauptverfasser:	Brener, Jacqui, Gall, Astrid, Hurst, Jacob, Batorsky, Rebecca, Lavandier, Nora, Chen, Fabian, Edwards, Anne, Bolton, Chrissy, Dsouza, Reena, Allen, Todd, Pybus, Oliver G, Kellam, Paul, Matthews, Philippa C, Goulder, Philip J R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology Cluster Analysis CTL response Development and progression Disease Progression Disease transmission Epitopes, T-Lymphocyte - genetics gag Gene Products, Human Immunodeficiency Virus - genetics Genetic aspects Genetic Variation High-Throughput Nucleotide Sequencing - methods Histocompatibility antigens HIV (Viruses) HIV Core Protein p24 - genetics HIV Infections - genetics HIV Infections - immunology HIV Infections - virology HIV-1 HIV-1 - classification HIV-1 - genetics HIV-1 - immunology HIV-1 - physiology HLA HLA histocompatibility antigens HLA-B Antigens - immunology Humans Male Physiological aspects RNA, Viral - blood RNA, Viral - genetics Sequence Analysis, RNA Superinfection Superinfection - genetics Superinfection - immunology Superinfection - virology T cells T-Lymphocytes, Cytotoxic - immunology Transmission pair Ultra-deep sequencing Viral Load Virus Replication
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B27:05 and HLA-B57:01 remain unknown. We here analyse two HIV-infected subjects expressing both HLA-B27:05 and HLA-B57:01. One subject maintained low-to-undetectable viral loads for more than a decade of follow up. The other progressed to AIDS in
ISSN:	1742-4690 1742-4690
DOI:	10.1186/s12977-018-0390-9