Fractional Flow Reserve Measurement by Coronary Computed Tomography Angiography: A Review with Future Directions

Invasive fractional flow reserve (FFR) measurement is currently the gold standard for coronary intervention. FFR measurement by coronary computed tomography angiography (FFR CT ) is a novel and promising imaging technology that permits noninvasive assessment of physiologically significant coronary lesions. FFR CT is capable of combining the anatomic information provided by coronary computed tomography angiography with computational fluid dynamics to compute FFR. To date, several studies have reported the diagnostic performance of FFR CT compared with invasive FFR measurement as the reference standard. Further studies are now being implemented to determine the clinical feasibility and economic implications of FFR CT techniques. This article provides an overview and discusses the available evidence as well as potential future directions of FFR CT .