Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease

We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in...

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Veröffentlicht in:	Emerging infectious diseases 2014-01, Vol.20 (1), p.114-117
Hauptverfasser:	Douet, Jean Yves, Zafar, Saima, Perret-Liaudet, Armand, Lacroux, Caroline, Lugan, Séverine, Aron, Naima, Cassard, Herve, Ponto, Claudia, Corbière, Fabien, Torres, Juan Maria, Zerr, Inga, Andreoletti, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood Blood-borne diseases Brain - metabolism Brain - pathology Cattle Creutzfeldt-Jakob Creutzfeldt-Jakob disease Creutzfeldt-Jakob Syndrome - blood Creutzfeldt-Jakob Syndrome - metabolism Creutzfeldt-Jakob Syndrome - pathology Disease Models, Animal Dispatch Erythrocytes - metabolism Human health and pathology Humans infectivity Leukocytes - metabolism Life Sciences Mice Mice, Transgenic Other prion Prions - genetics Prions - metabolism Prions - pathogenicity Santé publique et épidémiologie sCJD vCJD
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Zusammenfassung:	We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2001.130353