Leukocytosis associated with clozapine in elderly patient

Clozapine is the second-generation antipsychotic which is approved by the US Food and Drug Administration for the treatment of refractory schizophrenia. Clozapine is unfortunately associated with number of adverse effects, one of the chief concerns is agranulocytosis and occasionally leukocytosis, i.e. elevation of white blood cell count. In some cases, the leukocytosis may be persistent. We report the case of a 65-year-old patient diagnosed with schizophrenia, who also fulfilled the criteria of treatment-resistant schizophrenia, treated with clozapine as patient experienced leukocytosis.