Physiological Role of Leptin: A Bird’s Eye View

Since its discovery over fifteen years ago, Leptin remains the cornerstone for researchers because of its important role in central control of energy metabolism. Apart from role in energy metabolism, researchers have identified some newer but important roles of leptin in various areas like neuroendocrine function and regulation of metabolism-immune system interplay. Recently, recombinant human leptin emerged as a therapeutic intervention in various disorders. In this review, we highlighted important biology and physiology of leptin, its association with several disorders, and therapeutic interventions involving leptin.