Cardiac biomarkers for detection of coronary artery disease in the community

To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subj...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2024-12, Vol.14 (1), p.30514-11, Article 30514
Hauptverfasser:	Lind, Lars, Alfredsson, Joakim, Andersson, Jonas S. O., Andersson, Therese, Bergström, Göran, Ekblom, Örjan, Fagman, Erika, Fall, Tove, Hagström, Emil, Isholth, Hannes Holm, Janzon, Magnus, Jernberg, Tomas, Katsoularis, Ioannis, Leander, Karin, Leósdóttir, Margrét, Magnusson, Martin, Malinovschi, Andrei, Rosengren, Annika, GustavSmith, J., Spaak, Jonas, Svensson, Per, Söderberg, Stefan, Östgren, Carl Johan, Engström, Gunnar
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4019/592/75 692/53 Aged Biomarkers Biomarkers - blood blood Brain Cardiac and Cardiovascular Systems Clinical Medicine Computed Tomography Angiography Coronary Angiography Coronary Artery Disease Coronary Artery Disease - blood Coronary Artery Disease - diagnosis Coronary Artery Disease - diagnostic imaging Coronary atherosclerosis Coronary Vessels Coronary Vessels - diagnostic imaging Coronary Vessels - pathology Cross-Sectional Studies diagnosis diagnostic imaging Epidemiology Female Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Health Sciences Humanities and Social Sciences Humans Hälsovetenskap Kardiologi Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicin/Teknik Medicine/Technology Middle Aged multidisciplinary Natriuretic Peptide Natriuretic Peptide, Brain - blood NT-proBNP pathology Peptide Fragments Peptide Fragments - blood Population Public Health, Global Health, Social Medicine and Epidemiology Risk Factors Science Science (multidisciplinary) Troponin Troponin I Troponin I - blood
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To investigate whether coronary artery disease (CAD) burden is associated with plasma levels of the myocardial biomarkers Troponin I (TropI) and NT-proBNP in a large population-based sample using a cross-sectional design. Coronary computerized tomography (CT) angiography was performed in 25,859 subjects without a history of atherosclerotic disease from SCAPIS study (age 50–65, 52% women). TropI and NT-proBNP were measured in plasma. Segment involvement score (SIS) was the primary exposure and TropI the primary outcome. Both SIS and coronary artery calcium score, were associated with TropI levels following adjustment for age, sex and multiple confounders ( p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-024-82777-x