Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance

Plasma Progranulin Concentrations Are Increased in Patients with Type 2 Diabetes and Obesity and Correlated with Insulin Resistance

Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be involved in the pathogenesis of IR. In this s...

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Veröffentlicht in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.54-59-105
Hauptverfasser: Qu, Hua, Deng, Huacong, Hu, Zhenping
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Body Weight - physiology
Diabetes
Diabetes Mellitus, Type 2 - blood
Female
Glycosides
Health aspects
Humans
Insulin resistance
Insulin Resistance - physiology
Intercellular Signaling Peptides and Proteins - blood
Male
Middle Aged
Obesity
Obesity - blood
Physiological aspects
Type 2 diabetes
Waist Circumference - physiology
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Zusammenfassung:Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be involved in the pathogenesis of IR. In this study, we aim to investigate the concentrations of plasma progranulin in Chinese patients with obesity (OB) and type 2 diabetes mellitus (T2DM), and its relationship to IR. Plasma progranulin concentrations were significantly higher in the T2DM patients than in the normal glucose tolerant (NGT) subjects (P
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/360190