Neu2000 Potentiates a Kainate Response in Mouse Cortical Neurons

Neu2000, acting as an antioxidant with N-methyl-d-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly pot...

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Veröffentlicht in:	Journal of Pharmacological Sciences 2013/06/20, Vol.122(2), pp.149-152
Hauptverfasser:	Noh, Jihyun, Chung, Jun-mo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Cerebral Cortex Evoked Potentials - drug effects Fluorobenzenes - pharmacology kainic acid meta-Aminobenzoates - pharmacology Mice Mice, Inbred ICR Neurons - metabolism noise analysis Receptors, Kainic Acid - metabolism Receptors, Kainic Acid - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Salicylates - pharmacology Stimulation, Chemical voltage-clamp
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Zusammenfassung:	Neu2000, acting as an antioxidant with N-methyl-d-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents. In this study, we report that Neu2000 also dramatically enhances the activity of kainate (KA) receptors. Neu2000 noncompetitively and reversibly potentiated KA-evoked responses in a voltage-independent manner, mainly by increasing the open probability of KA receptor channels.
ISSN:	1347-8613 1347-8648
DOI:	10.1254/jphs.13023SC