Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis

Genetic risk score based on the prevalence of vertebral fracture in Japanese women with osteoporosis

A genetic risk score (GRS) was developed for predicting fracture risk based on the prevalence of vertebral fractures in 441 Japanese females with osteoporosis. A total of 979 (858 nonsynonymous and 121 silent) single-nucleotide polymorphisms (SNPs) located in 74 osteoporosis-susceptibility genes wer...

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Veröffentlicht in:Bone Reports 2016-12, Vol.5, p.168-172
Hauptverfasser: Zhou, Heying, Mori, Seijiro, Ishizaki, Tatsuro, Takahashi, Atsushi, Matsuda, Koichi, Koretsune, Yukihiro, Minami, Shiro, Higashiyama, Masahiko, Imai, Shinji, Yoshimori, Kozo, Doita, Minoru, Yamada, Akira, Nagayama, Satoshi, Kaneko, Kazuo, Asai, Satoshi, Shiono, Masaki, Kubo, Michiaki, Ito, Hideki
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Sprache:eng
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Zusammenfassung:A genetic risk score (GRS) was developed for predicting fracture risk based on the prevalence of vertebral fractures in 441 Japanese females with osteoporosis. A total of 979 (858 nonsynonymous and 121 silent) single-nucleotide polymorphisms (SNPs) located in 74 osteoporosis-susceptibility genes were genotyped and evaluated for their association with fracture prevalence. Four SNPs (protein kinase domain containing, cytoplasmic [ ; rs4952590], CDK5-regulatory subunit-associated protein 1-like 1 [ ; rs4712556], wingless-type MMTV-integration site family member 16 [ ; rs2707466], and G-patch domain-containing gene 1 [ ; rs10416265]) showed a significant association (  
ISSN:2352-1872
2352-1872
DOI:10.1016/j.bonr.2016.07.001