Characterization of host substrates of SARS-CoV-2 main protease
The main protease (M pro ) plays a crucial role in coronavirus, as it cleaves viral polyproteins and host cellular proteins to ensure successful replication. In this review, we discuss the preference in the recognition sequence of M pro based on sequence-based studies and structural information and...
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Veröffentlicht in: | Frontiers in microbiology 2023-08, Vol.14, p.1251705-1251705 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | The main protease (M
pro
) plays a crucial role in coronavirus, as it cleaves viral polyproteins and host cellular proteins to ensure successful replication. In this review, we discuss the preference in the recognition sequence of M
pro
based on sequence-based studies and structural information and highlight the recent advances in computational and experimental approaches that have aided in discovering novel M
pro
substrates. In addition, we provide an overview of the current understanding of M
pro
host substrates and their implications for viral replication and pathogenesis. As M
pro
has emerged as a promising target for the development of antiviral drugs, further insight into its substrate specificity may contribute to the design of specific inhibitors. |
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ISSN: | 1664-302X 1664-302X |
DOI: | 10.3389/fmicb.2023.1251705 |