A novel and practical asymmetric synthesis of eptazocine hydrobromide

In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of -( -trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in...

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Veröffentlicht in:	Beilstein journal of organic chemistry 2018-09, Vol.14 (1), p.2340-2347
Hauptverfasser:	Li, Ruipeng, Liu, Zhenren, Chen, Liang, Pan, Jing, Lin, Kuaile, Zhou, Weicheng
Format:	Artikel
Sprache:	eng
Schlagworte:	alkylation asymmetric catalysis Asymmetric synthesis Catalysis Chemistry eptazocine Full Research Paper Hydrogenation Mannich cyclization Pharmaceutical industry
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Beschreibung
Zusammenfassung:	In order to prepare eptazocine hydrobromide effectively, a novel, mild and practical asymmetric process was developed starting from 1-methyl-7-methoxy-2-tetralone under the catalysis of -( -trifluoromethylbenzyl)cinchonidinium bromide. The reaction conditions were optimized to obtain the product in excellent overall yield and purity.
ISSN:	1860-5397 2195-951X 1860-5397
DOI:	10.3762/bjoc.14.209