A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emph...

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Veröffentlicht in:Clinical and applied thrombosis/hemostasis 2021, Vol.27, p.10760296211051764
Hauptverfasser: Klein, Mark, Dao, Vinh, Khan, Fatima
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - metabolism
COVID-19 - mortality
COVID-19 - pathology
Humans
Inflammation - complications
Inflammation - metabolism
Inflammation - mortality
Inflammation - pathology
Multiple Organ Failure - complications
Multiple Organ Failure - metabolism
Multiple Organ Failure - mortality
Multiple Organ Failure - pathology
Platelet Activating Factor - metabolism
Respiratory Distress Syndrome - complications
Respiratory Distress Syndrome - metabolism
Respiratory Distress Syndrome - mortality
Respiratory Distress Syndrome - pathology
Review
SARS-CoV-2 - physiology
Severity of Illness Index
Thrombosis - complications
Thrombosis - metabolism
Thrombosis - mortality
Thrombosis - pathology
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Zusammenfassung:The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.
ISSN:1076-0296
1938-2723
1938-2723
DOI:10.1177/10760296211051764