Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted from Chlorella Pyrenoidosa

Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from were investigated using lipopolysaccharide (LPS)-stimulated RAW...

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Veröffentlicht in:	Marine drugs 2019-10, Vol.17 (10), p.586
Hauptverfasser:	Zhang, Ruilin, Chen, Jian, Mao, Xinwu, Qi, Ping, Zhang, Xuewu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Ageing Aging Aging (artificial) Aging - drug effects Algae Animal models Animals anti-aging anti-aging properties anti-inflammation Anti-Inflammatory Agents - pharmacology antioxidant enzymes Antioxidants Antioxidants - metabolism Biological Products - pharmacology brain Chlorella Chlorella - chemistry Chlorella pyrenoidosa Cytokines Cytokines - metabolism D-Galactose digestive system Disease Models, Animal Galactose Galactose - metabolism Inflammation Inflammation - drug therapy Inflammation - metabolism Interleukin 6 Interleukin-6 - metabolism Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Male Mice Mice, Inbred C57BL Morphology NF-kappa B - metabolism nf-κb NF-κB protein Nitric oxide Nitric Oxide - metabolism Oxidative stress Oxidative Stress - drug effects pigment–protein complex ppars Proteins RAW 264.7 Cells Senescence Superoxide dismutase Superoxide Dismutase - metabolism transcription factor NF-kappa B tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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Zusammenfassung:	Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and D-galactose (D-gal)-induced aging in a murine model. Results indicated that PPC inhibits the production of the inflammatory cytokines TNF-α and IL-6, and the inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. It also protected mice from D-gal induced informatory aging by increasing the activity of the antioxidant enzyme, such as superoxide dismutase (SOD), inhibiting D-gal-induced NF-κB upregulation, and increasing PPARs expression in the brain and gut. The findings indicated that PPC has favorable anti-inflammatory and anti-aging properties, and could be useful in the treatment of acute inflammation and senescence diseases.
ISSN:	1660-3397 1660-3397
DOI:	10.3390/md17100586