Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications

Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-ph...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-11, Vol.25 (23), p.5601
Hauptverfasser:	Lloyd, Carissa M, Colgin, Neil, Cobb, Steven L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Animals Biological activity Chemistry, Pharmaceutical Fluorides fluorine fluoromethyl ketone Humans Hydrogenation Interrogation Ketones Ketones - chemical synthesis Ketones - pharmacology Medical treatment Methods peptide Peptide Fragments - chemical synthesis Peptide Fragments - pharmacology peptide modification peptide synthesis Peptides Pharmaceutical sciences Potassium Protease inhibitors Protease Inhibitors - chemical synthesis Protease Inhibitors - pharmacology Proteinase inhibitors Review therapeutic
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Beschreibung
Zusammenfassung:	Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25235601