Dupilumab improves lung function in patients with uncontrolled, moderate-to-severe asthma

Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2 inflammation. In the phase 3 LIBERTY ASTHMA QUEST trial (NCT02414854) in patients with uncontrolled, moderate-to-severe asthma, add-on dupilumab 200 mg or 300 mg every 2 weeks reduced exacerbations and improved forced expiratory volume in 1 s (FEV ) and quality of life over 52 weeks. This analysis evaluates dupilimab's effect on lung function in the overall population, and subgroups with baseline elevated type 2 inflammatory biomarkers. Patients were randomised to 52 weeks of subcutaneous dupilumab 200 mg every 2 weeks, 300 mg every 2 weeks, or matched-volume placebos. Lung function outcomes were analysed in the overall population, in patients with ≥150 eosinophils·µL , ≥300 eosinophils·µL , ≥25 ppb fractional exhaled nitric oxide ( ), and both ≥150 eosinophils·µL and ≥25 ppb , at baseline. Dupilumab treatment (200 mg and 300 mg every 2 weeks) resulted in significant improvements placebo after 52 weeks in pre-bronchodilator FEV (0.20 and 0.13 L, respectively, placebo) and post-bronchodilator FEV (0.19 and 0.13 L, respectively), forced vital capacity (FVC) (0.20 and 0.14 L, respectively), forced expiratory flow (0.19 and 0.13 L·s , respectively) and pre-bronchodilator FEV /FVC ratio (1.75% and 1.61%, respectively) in the overall population (p