Development of a penem antibiotic against Mycobacteroides abscessus

β-lactams are the most widely used antibiotic class to treat bacterial infections in humans. Mycobacteroides abscessus is an emerging pulmonary pathogen resistant to most antibiotics, including penicillins and cephalosporins. With no current FDA-approved treatment and cure rates

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Bibliographische Detailangaben
Veröffentlicht in:	Communications biology 2020-12, Vol.3 (1), p.741-5, Article 741
Hauptverfasser:	Batchelder, Hunter R., Story-Roller, Elizabeth, Lloyd, Evan P., Kaushik, Amit, Bigelow, Kristina M., Maggioncalda, Emily C., Nuermberger, Eric L., Lamichhane, Gyanu, Townsend, Craig A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/309 631/326/22 Antibiotics Biology Biomedical and Life Sciences Cephalosporins Clinical isolates Cystic fibrosis Drug resistance Life Sciences Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Multidisciplinary Sciences Patients Pharmacokinetics Science & Technology Science & Technology - Other Topics Toxicity β Lactamase β-Lactam antibiotics
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Beschreibung
Zusammenfassung:	β-lactams are the most widely used antibiotic class to treat bacterial infections in humans. Mycobacteroides abscessus is an emerging pulmonary pathogen resistant to most antibiotics, including penicillins and cephalosporins. With no current FDA-approved treatment and cure rates
ISSN:	2399-3642 2399-3642
DOI:	10.1038/s42003-020-01475-2