Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity

Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2019-06, Vol.24 (11), p.2121
Hauptverfasser:	Wang, Ning, Świtalska, Marta, Wang, Li, Shaban, Elkhabiry, Hossain, Md Imran, El Sayed, Ibrahim El Tantawy, Wietrzyk, Joanna, Inokuchi, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	antiproliferative activity Antiproliferatives Biological properties Colon Colon cancer Colorectal cancer cryptolepine Cytotoxicity isocryptolepine Leukemia Localization Lung cancer neocryptolepine Review structure activity relationships Tumor cell lines
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules24112121