Association between Exposure to Beta 2 Agonists and Corticosteroids and Acquiring Benign Joint Hypermobility Syndrome among Asthmatic Patients: a Case-Control Study

Background:Beta2 (β2) agonists as relievers and corticosteroids as controllers are the mainstay drugs for asthma treatment. Benign Joint Hypermobility Syndrome (BJHS) is a connective tissue disorder with musculoskeletal symptoms.We had examined the possible association between the use of β2 agonists...

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Veröffentlicht in:Sudan journal of medical sciences 2017-12, Vol.12 (4), p.215-230
Hauptverfasser: Diab, Alsarah Mutwakil Abbas, Suliman, Eman MutwakilAhmedAlmostafa, Abdallah, AyatAbdallah Hassan, Dyab, Mohamed AbdelhadiElzubair, Awadalla, Tanzeel Omer Elamin, Kirkisawi, Naila Mubarak, Husain, Nazik Elmalaika Obaid Seid Ahmed
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Sprache:eng
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Zusammenfassung:Background:Beta2 (β2) agonists as relievers and corticosteroids as controllers are the mainstay drugs for asthma treatment. Benign Joint Hypermobility Syndrome (BJHS) is a connective tissue disorder with musculoskeletal symptoms.We had examined the possible association between the use of β2 agonists and corticosteroids and acquiring BJHS in asthmatic patients.Methods:This was a case-control, hospital-based study including a group of asthmatics who had BJHS (cases), compared with a matched group of asthmatics without BJHS (controls) for the β2 agonists and corticosteroids past and current pattern of use. Information was collected by face-to-face interview and clinical examination and from subjects’ medical records using pre-structured questionnaire. BJHS diagnosis was based on the revised Brighton criteria. Asthma severity was reflected by a score, which was calculated from the asthma questionnaire. Comparison of exposure was done by Calculation of Odds Ratio.Results:Development of BJHS was found to be significantly associated with chronicity of asthma of average duration of 13.2 years, and hence to prolonged use of β2 agonists and/or corticosteroids (OR 1.019; 95% CI 0.999 - 1.039, P=0.006)Exposure to β2 agonist and corticosteroid (87 and 79 cases and controls respectively P=0.05)high asthma score (42.9 ± 9.8 and 40.4 ± 8.3 among cases and controls respectively, P=0.011) were significantly associated with the development of BJHS.
ISSN:1858-8530
1858-5051
DOI:10.18502/sjms.v12i4.1353