Changes in pattern electroretinogram after application of 0.01% atropine eye drops

Dear Sir, We want to report a profound, reversible reduction in p50 (N35–p50) amplitude in the pattern Electroretinogram (PERG) of eyes treated with low dose (0.01%) atropine eye drops without a significant change in the implicit time. [1] Potential side effects of topical atropine eye drops include pupillary mydriasis, reduced accommodation, light sensitivity, near vision blur, headache, ocular allergy, periocular dermatitis, angle closure glaucoma, drug-related retinal toxicity, and mydriasis-related phototoxicity. The investigators of Atropine in the Treatment of Myopia studies have reported a lack of retinal toxicity with long term (2 years) use of atropine eye drops in children with progressive myopia using multifocal ERG (MFERG) testing.